Meet the surgeon
Andrew Timberlake, MD, PhD 
Dr. Timberlake is an academic plastic surgeon, and has earned both national and international recognition for his research, including prestigious awards from the Plastic Surgery Research Council, the American Association of Plastic Surgeons, and the Northeastern Society of Plastic Surgeons. His PhD thesis work, completed with Rockefeller University President Richard Lifton, identified a novel mechanism of genetic inheritance causing craniofacial conditions, earning him the top thesis prize across all departments at Yale University. To date, his research has discovered more than 30 genes that shape development of the face and craniofacial skeleton, resulting in over 50 publications in the world’s top scientific journals.
During his six years of training, he participated in over 2,000 cosmetic and reconstructive procedures of the face, nose, breast, and body, learning from world experts in each. Dr. Timberlake apprenticed under world renowned facial plastic surgeon Dr. David Rosenberg to obtain further training in facial rejuvenation, with a particular focus on the deep plane facelift. He sought this training with Dr. Rosenberg because of their shared principles and aesthetic, namely a patient-centered approach to achieving the most natural, durable results with minimal downtime. He ultimately joined Dr. Rosenberg, Dr. Benjamin Paul, and Dr. Jessica Lattman in practice at Manhattan Facial Surgery Suites.
Education
After studying Molecular Biophysics and Biochemistry at Yale, he continued his medical and graduate studies at Yale, graduating cum laude from the medical school and with a PhD in Genetics. At graduation he was awarded the MD/PhD Prize for most outstanding achievement in both clinical and research efforts. Dr. Timberlake’s exposure to plastic surgery began in medical school when he spent time visiting some of the world’s foremost plastic surgeons to study their techniques. He completed his residency in Plastic and Reconstructive Surgery at NYU Langone’s Wyss Department of Plastic Surgery, ranked the #1 plastic surgery residency program in the United States during his time there.
Hansjorg Wyss Department of Plastic Surgery, New York University, New York, NY
Integrated Plastic Surgery ResidencyYale School of Medicine, New Haven, CT
M.D./Ph.D. awarded May 2018 with distinction, Cum Laude
Thesis work, “Exome Sequencing Reveals Novel Genetic Causes of Craniosynostosis,” performed in the lab of
Dr. Richard P. Lifton; awarded top thesis across all departments university-wide at Yale
Yale University, Calhoun College, New Haven, CT
B.S. in Molecular Biophysics and Biochemistry, May 2011
Brady-Johnson Program for Studies in Grand Strategy 2010-2011
Mountain Brook High School, Mountain Brook, AL
Advanced Diploma, May 2007
Awarded “Most Outstanding Graduating Senior”
The Porter Prize, Yale University, 2017: Awarded by Yale University for the best graduate thesis submitted across all departments university-wide in the graduating class
2022 Best Craniofacial Plastic and Reconstructive Surgery Paper; selected from all papers published in PRS internationally (awarded by the ASMS at Plastic Surgery the Meeting, Austin, 2023).
Blair O. Rogers Award for Basic Science Research: Awarded for the best research presentation at the Hansjorg Wyss Department of Plastic Surgery’s annual research day. Recipient of this award the past 2 years. (New York, 2022 and 2023).
Best Resident Research Presentation, Northeastern Society of Plastic Surgeons, Newport, RI 2022
Clifford Snyder Award, Plastic Surgery Research Council Annual Meeting, Cleveland, OH 2023: Awarded to the best paper presented by a plastic surgery resident or fellow at the annual PSRC meeting
Gingrass Memorial Award, Plastic Surgery Research Council Annual Meeting, Durham, NC 2017: Awarded to the best paper presented by a medical student at the annual PSRC meeting
Invited Keynote Speaker at the Broad Center for Mendelian Genomics (Harvard University/MIT, May 2017)
Invited Keynote Speaker at the NIH National Human Genome Research Institute (Washington DC, 2017)
Invited Keynote Speaker at the NIH National Institute for Dental and Craniofacial Research (Washington DC, 2022)
AAPS Cannon Medical Student
Travel Fellowship to attend the American College of Surgeons Congress, Washington, D.C. 2014
-Recipient of several fellowships to conduct research at the Yale School of Medicine, the Charité Universitätsmedizin in Berlin, Germany, the Cambridge Research Institute in Cambridge, England, and the UCL Cancer Institute in London (2008-2011)
USA Today All-American Scholar-Athlete– awarded to top 25 scholar-athletes in the country from nominee pool of 56,000 athletes (2007)
Intel Science Talent Search– National Semifinalist 2007
Quiat, D,* Timberlake A.T.*, et al. (2023). Damaging variants in FOXI3 cause microtia and craniofacial microsomia. Genet Med. Jan;25(1):143-150.
Timberlake, A.T. et al. (2023). De novo mutations in 555 trios implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis. (American Journal of Human Genetics, in press).
Kindishora A., Allington G., McGee S., Mekbib K., Gainullin V., Timberlake, A.T., Nelson-Williams, C., et al. (2023). Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts. Nature Medicine. Mar;29(3):667-678.
Timberlake, A.T. et al. (2023). De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis. Hum Genet. Jan;142(1):21-32.
Timberlake, A.T. (2023). Molecular scalpels: the future of pediatric craniofacial surgery? Plastic and Reconstructive Surgery. Mar 14.
Timberlake A.T. (2023). SMAD6 variants in nonsyndromic craniosynostosis. Eur J Hum Genet. Feb 16.
Junn A, Dinis J, Long A, Timberlake AT, Persing JA, Alperovich M. (2023). Quantifying the Impact of Genetics on Neurocognition in Non-Syndromic Sagittal Craniosynostosis. Plast Reconstr Surg. Mar 14.
Duy, P.Q.*, Timberlake, A.T.*, Lifton, R.P., and Kahle, K.T. (2022). Molecular genetics of human developmental neurocranial anomalies: towards “precision surgery”. Cereb Cortex. 10.1093/cercor/bhac249.
Duy P, Weise S, Marini C, … Timberlake, A.T., … Kahle, K.T. (2022). Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature Neuroscience. 2022 Apr;25(4):458-473.
Timberlake, A. T., Junn, A., Flores, R., Staffenberg, D. A., Lifton, R. P., & Persing, J. A. (2022). Genetic Influence on Neurodevelopment in Nonsyndromic Craniosynostosis. Plast Reconstr Surg. doi:10.1097/PRS.0000000000008976.
Timberlake, A.T. et al, (2021). Haploinsufficiency of SF3B2 causes craniofacial microsomia. Nature Communications. 2021 Aug 3;12(1):4680. doi: 10.1038/s41467-021-24852-9.
Calpena, E., Wurmser, M., McGowan, S. J., Atique, R., Bertola, D. R., Cunningham, M. L., Lifton, R.P, Timberlake, A.T., Wilkie, A. O. M. (2022). Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders. J Med Genet, 59(2), 165-169.
Parenti, I., Lehalle, D., Nava, C., Torti, E., Leitao, E., Person, R., Timberlake, A.T.,. . . Mignot, C. (2021). Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy. Hum Genet, 140(7), 1109-1120.
Kerner, G., Bouaziz, M., Cobat, A., Bigio, B., Timberlake, A. T., Bustamante, J., . . . Abel, L. (2020). A genome-wide case-only test for the detection of digenic inheritance in human exomes. Proc Natl Acad Sci U S A, 117(32), 19367-19375. doi:10.1073/pnas.1920650117
Jin, S. C., Dong, W., Kundishora, A. J., Panchagnula, S., Moreno-De-Luca, A., Furey, C. G., Timberlake, A.T.,. . . Kahle, K. T. (2020). Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine, 26(11), 1754-1765. doi:10.1038/s41591-020-1090-2
Timberlake, A. T., Jin, S. C., Nelson-Williams, C., Wu, R., Furey, C. G., Islam, B., . . . Lifton, R. P. (2019). Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis. Proc Natl Acad Sci U S A, 116(30), 15116-15121. doi:10.1073/pnas.1902041116
Timberlake, A. T., Furey, C. G., Choi, J., Nelson-Williams, C., Yale Center for Genome, A., Loring, E., . . . Lifton, R. P. (2017). De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1709255114
Timberlake, A. T., Choi, J., Zaidi, S., Lu, Q., Nelson-Williams, C., Brooks, E. D., . . . Lifton, R. P. (2016). Two locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles. Elife, 5. doi:10.7554/eLife.20125
Timberlake, A. T., & Persing, J. A. (2018). Genetics of Nonsyndromic Craniosynostosis. Plast Reconstr Surg, 141(6), 1508-1516. doi:10.1097/PRS.0000000000004374
Timberlake, A. T., & Steinbacher, D. M. (2018). Familial Aggregation of Plastic Surgical Procedures. Plast Reconstr Surg, 142(5), 782e-785e. doi:10.1097/PRS.0000000000004909
Timberlake, A. T., Wu, R., Nelson-Williams, C., Furey, C. G., Hildebrand, K. I., Elton, S. W., . . . Lifton, R. P. (2018). Co-occurrence of frameshift mutations in SMAD6 and TCF12 in a child with complex craniosynostosis. Hum Genome Var, 5, 14. doi:10.1038/s41439-018-0014-x
Timberlake, A. T., Wu, R. T., Cabrejo, R., Gabrick, K., & Persing, J. A. (2018). Harnessing Social Media to Advance Research in Plastic Surgery. Plast Reconstr Surg, 142(4), 1094-1100. doi:10.1097/PRS.0000000000004811
Wu, R. T., Timberlake, A. T., Abraham, P. F., Gabrick, K. S., Lu, X., Peck, C. J., . . . Persing, J. A. (2020). SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plast Reconstr Surg, 145(1), 117e-125e. doi:10.1097/PRS.0000000000006319
Wu, R. T., Timberlake, A. T., Bruckman, K. C., & Steinbacher, D. (2020). Concurrent Platysmaplasty and Genioplasty Using a Novel Intraoral Approach. Plast Reconstr Surg, 145(1), 80-83. doi:10.1097/PRS.0000000000006392
Brooks, E. D., Beckett, J. S., Yang, J., Timberlake, A. T., Sun, A. H., Chuang, C., & Persing, J. A. (2018). The Etiology of Neuronal Development in Craniosynostosis: A Working Hypothesis. J Craniofac Surg, 29(1), 49-55. doi:10.1097/SCS.0000000000004040
Chesler, D., Bram, R., Antwi, P., Timberlake, A. T., DiLuna, M. L., & Kahle, K. T. (2018). Non-syndromic single-suture craniosynostosis in triplets. Childs Nerv Syst, 34(6), 1241-1245. doi:10.1007/s00381-018-3754-5
Duran, D., Zeng, X., Jin, S. C., Choi, J., Nelson-Williams, C., Yatsula, B. Timberlake, A.T., . . . Kahle, K. T. (2019). Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron, 101(3), 429-443 e424. doi:10.1016/j.neuron.2018.11.041
Furey, C., Antwi, P., Duran, D., Timberlake, A. T., Nelson-Williams, C., Matouk, C. C., . . . Kahle, K. T. (2018). 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus. Cold Spring Harb Mol Case Stud, 4(5). doi:10.1101/mcs.a003145
Furey, C. G., Choi, J., Jin, S. C., Zeng, X., Timberlake, A. T., Nelson-Williams, C., . . . Kahle, K. T. (2018). De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. Neuron, 99(2), 302-314 e304. doi:10.1016/j.neuron.2018.06.019
Furey, C. G., Timberlake, A. T., Nelson-Williams, C., Duran, D., Li, P., Jackson, E. M., & Kahle, K. T. (2017). Xp22.2 Chromosomal Duplication in Familial Intracranial Arachnoid Cyst. JAMA Neurol, 74(12), 1503-1504. doi:10.1001/jamaneurol.2017.3399
Furey, C. G., Zeng, X., Dong, W., Jin, S. C., Choi, J., Timberlake, A. T., . . . Kahle, K. T. (2018). Human Genetics and Molecular Mechanisms of Congenital Hydrocephalus. World Neurosurg, 119, 441-443. doi:10.1016/j.wneu.2018.09.018
Gabrick, K., Walker, M., Timberlake, A., Chouiari, F., Saberski, E., & Steinbacher, D. (2019). Autologous Fat Grafting’s Effect on Edema and Ecchymoses in Primary Open Rhinoplasty. Aesthet Surg J. doi:10.1093/asj/sjz075
Persing, S., Timberlake, A., Madari, S., & Steinbacher, D. (2018). Three-Dimensional Imaging in Rhinoplasty: A Comparison of the Simulated versus Actual Result. Aesthetic Plast Surg, 42(5), 1331-1335. doi:10.1007/s00266-018-1151-9
Rohrich, R. J., Timberlake, A. T., & Afrooz, P. N. (2017). Revisiting the Fundamental Operative Principles of Plastic Surgery. Plast Reconstr Surg, 140(6), 1315-1318. doi:10.1097/PRS.0000000000003909
Flowers, G. P., Timberlake, A. T., McLean, K. C., Monaghan, J. R., & Crews, C. M. (2014). Highly efficient targeted mutagenesis in axolotl using Cas9 RNA-guided nuclease. Development, 141(10), 2165-2171. doi:10.1242/dev.105072
Svejda, B., Kidd, M., Timberlake, A., Harry, K., Kazberouk, A., Schimmack, S., . . . Modlin, I. M. (2013). Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors. Cancer Sci, 104(7), 844-855. doi:10.1111/cas.12174
Chin, A., Svejda, B., Gustafsson, B. I., Granlund, A. B., Sandvik, A. K., Timberlake, A., . . . Kidd, M. (2012). The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. Am J Physiol Gastrointest Liver Physiol, 302(3), G397-405. doi:10.1152/ajpgi.00087.2011
Timberlake
Ethos
Andrew Timberlake, MD, PHD
Ethos
Ethos
Dr. Timberlake apprenticed under world-renowned pioneer of the extended deep plane facelift, Dr. David Rosenberg, to master the art of achieving completely natural, elegant results in facial surgery. The two surgeons share the philosophy that facelift surgery is meant to restore one’s natural beauty, never changing one’s face or creating an ‘operated’ look.
Why Choose Dr. Timberlake?
Dr. Andrew Timberlake is a plastic surgeon with years of education and rigorous training. Following his training, he chose to focus his practice primarily on cosmetic surgery of the face, as opposed to the breasts and body. This specialty differentiates Dr. Timberlake from other surgeons in New York, allowing him to focus his surgical efforts above the shoulders.
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If you’re ready to take the plunge into plastic surgery, you’ve come to the right place. Andrew Timberlake, MD, PhD is excited to help you achieve a rejuvenated and optimally balanced appearance, that perfectly fits your aesthetic.
